| Knebel W, Bergsma TT, Dagdigian C, Hane J, Gastonguay MR. Utilizing NONMEM 7 and the Intel Fortran Compiler in a Distributed Computing Environment. PAGE 2010. |
| Gastonguay MR, Gillespie WR, Bauer RJ. Comparison of MCMC simulation results using NONMEM 7 or WinBUGS with BUGSModelLibrary. PAGE 2010. |
| Sweeney KR, Gastonguay MR, Benincosa L, Cronenberger CL, Glue P, Malhotra BK . Exposure-response modeling and clinical trial simulation of the effect of tolterodine on QT intervals in healthy volunteers. Drug Discov Ther. 2010 ;4(1):44-53. |
| Knebel W, Rao N, Uchimura T, Mori A, Fisher J, Gastonguay MR, Chaikin P. Population pharmacokinetic analysis of istradefylline in healthy subjects and in patients with parkinson’s disease. J Clin Pharmacol. 2010 Mar 3. [Epub ahead of print] |
| SSu F, Nicolson SC, Gastonguay MR, Barrett JS, Adamson PC, Kang DS, Godinez RI, Zuppa AF. Population pharmacokinetics of dexmedetomidine in infants after open heart surgery. Anesth Analg. 2010 May;110(5):1383-92. |
| James A. Rogers, Ph.D. An Issue in Controlling the Type I Error Rate with Adaptive Designs Using Time-to-Event Endpoints. 3rd Annual FDA/MTLI Medical Device and IVD Statistics Workshop. 28 April 2010. |
| Nathanael Dirks, Marc R. Gastonguay, William R. Gillespie, William Knebel, Matthew M. Riggs, John C. Panetta, and Bernd Meibohm. Comparative Performance of Bayesian Markov Chain Monte Carlo and Maximum Likelihood Population Estimation Methods when Applied to Nonlinear Pharmacokinetics of Monoclonal Antibodies. |
| JP Ravva, M R Gastonguay, J L French, T G Tensfeldt, and H M Faessel. Quantitative Assessment of Exposure–Response Relationships for the Efficacy and Tolerability of Varenicline for Smoking Cessation. Clinical Pharmacology and Therapeutics. 27 Jan 2010. |
| Peterson MC, Riggs MM. A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling. Bone. 2010 Jan; 46: 49-63. |
| Mondick JT, Johnson BM, Haberer LJ, Sale ME, Adamson PC, Coté CJ, Croop JM, Russo MW, Barrett JS, Hoke JF. Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1-48 months. Eur J Clin Pharmacol. 2010 Jan;66(1):77-86. |
| Marc R. Gastonguay. The Impact of Missing Data on Model Evaluation. ACOP 2009. |
| James A. Rogers, Matthew M. Riggs, Monte Coffiner, William R. Gillespie, Robert Burford, Francis Vanderbist, Sophie De Niet, Marc R. Gastonguay. Clinical Trial Simulation to Compare Adaptive and Fixed Designs for a Phase 3 Clinical Trial of Nacystelyn® (L-Lysine-N-acetyl-L-cysteinate) for Cystic Fibrosis. |
| William R. Gillespie, James A. Rogers, Kaori Ito, Marc R. Gastonguay. Population Dose-Response Model for ADAS-cog Scores in Patients with Alzheimers Disease by Meta-Analysis of a Mixture of Summary and Individual Data. |
| Timothy Bergsma, Jeffrey Hall, Michael S. Smith, Malaz A. AbuTarif, David R. Taft, William Knebel, Joseph Hebert, James Rogers, Jeffrey T. Hane, and Marc R. Gastonguay. Development and Pilot Evaluation of a High-Performance Computing System for Web-Based Deployment of Pharmacometrics Applications in a Multi-User Training Environment. |
| Riggs MM, Peterson MC, Gastonguay MR. A Systems Biology Model to Describe Long-Term Bone Remodeling Effects of Estrogen in Menopausal and Postmenopausal Women. |
| Gillespie B, Rogers JA, Ito K, Gastonguay MR. Population Dose-Response Model for ADAS-cog Scores in Patients with Alzheimer's Disease by Meta-Analysis of a Mixture of Summary and Individual Data. |
| Gillespie B, Gastonguay MR. Prototype Model Library for Bayesian Pharmacokinetic/Pharmacodynamic (PKPD) Modeling in Winbugs. |
| Fisher J, Gastonguay MR, Knebel W, Gibiansky L, Wire MB. Population Pharmacokinetic Modeling of Fosamprenavir in Pediatric HIV- Infected Patients. American Conference on Pharmacometrics, 2008. |
| Gillespie WR, Gastonguay MR, Knebel W, Georgalis G. Open Source Software Tools for Parallel Computation of Multiple MCMC Chains with WinBUGS. American Conference on Pharmacometrics, 2008. |
| Knebel W, Bergsma T, Fisher J, Georgalis G, Gibiansky L, Gillespie WR, Riggs MM, and Gastonguay MR. Facilitating the Pharmacometrics Work-Flow with the MItools R Package. American Conference on Pharmacometrics, 2008. |
| Riggs MM, Bergsma TT, Gillespie WR, Gastonguay MR, Sprenger KJ. Use of Rpad, an Open-Source, Interactive, Web-Based Analysis Program, for Visualization During Model-Based Drug Development of Adipiplon, a GABAA Receptor Partial Agonist Under Investigation for the Treatment of Insomnia. American Conference on Pharmacometrics, 2008. |
| Gillespie WR, Gastonguay MR, and Knebel W. Bayesian Approaches to Mixed Effects Models for Ordered Categorical Data. 2007 AAPS Annual Meeting & Exposition: Population PK/PD Analysis and Clinical Trial Simulations Session, 2007. |
| Faessel HM, Rawa P, Gastonguay MR, Rohrbacher KD, Tenfeldt TG. Population Pharmacokinetic Analysis of Varenicline in Adult Smokers. Clin Pharmacol Ther 2007; 81(S1), Abstract PI-26: S20-21. |
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| Rawa P, Faessel H, Gastonguay MR, Tensfeldt TG, Reeves K. Quantitative Assessment of Exposure-Response Relationships for the Efficacy and Tolerability of Varenicline for Smoking Cessation. Clin Pharmacol Ther 2007; 81(S1), Abstract PII-73: S72. |
| Agoram B, Heatherington AC, Gastonguay MR. Development and evaluation of a population pharmacokinetic-pharmacodynamic model of darbepoetin alfa in patients with nonmyeloid malignancies undergoing multicycle chemotherapy. AAPS Journal. 8(3), 2006. |
| Riggs M. Exposure-response (PK-PD) applied to model-based drug development: A case study of Drug X. FDA/Industry Statistics Workshop (2006) Parallel Session 14: Case Studies in Modeling and Simulation, Abstract. |
| Gastonguay MR, Gibiansky L. Acknowledging and Incorporating Uncertainty in Model-Based Inferences. ECPAG Conference (2006) Workshop Poster Session, Abstract. |
| Gibiansky L and MR Gastonguay. R/NONMEM Toolbox for Simulation from Posterior Parameter (Uncertainty) Distributions. L. Gibiansky and M.R. Gastonguay. PAGE ( 2006) Abstract 958. |
| Gibiansky E, Gibiansky L. Model-based drug development: Optimization of AQUAVAN® injection dosing for minimal-to-moderate sedation. PAGE 15 (2006) Abstract 959. |
| Mondick JT, Gibiansky L, Gastonguay MR, Veal GJ, Barrett JS. Acknowledging parameter uncertainty in the simulation-based design of an actinomycin-D pharmacokinetic study in pediatric patients with Wilms’ Tumor or rhabdomyosarcoma. PAGE 15 (2006) Abstract 938. |
| Gastonguay MR, Gibiansky L. Acknowledging Parameter Uncertainty by Simulating from Posterior Distributions with NONMEM and R. MUFPADA Annual Meeting (2006) Abstract. |
| Gastonguay MR, El-Tahtawy A. Modeling and Simulation Guided Design of a Pediatric Population Pharmacokinetic Trial for Hydromorphone. The AAPS Journal. Vol. 7, No. S2, Abstract W5318, 2005. |
| Gastonguay MR and El-Tahtawy A. Effect of NONMEM Minimization Status and Number of Replicates on Bootstrap Parameter Distributions for Population Pharmacokinetic Models: A Case Study. Clinical Pharmacology and Therapeutics; 77(2), Abstract P2, 2005. |
| Gibiansky E, Gibiansky L, Enriquez J. Population Pharmacokinetic Model of Sedative Doses of GPI 15715 and Propofol Liberated from GPI 15715. Clinical Pharmacology and Therapeutics; 77(2), Abstract PI-154, 2005. |
| Gastonguay MR, Venitz J, Steffen R, Hackman J. Population Pharmacokinetic–Pharmacodynamic Modeling of Efaproxiral in Cancer Patients Receiving Radiation Therapy. Clinical Pharmacology and Therapeutics; 77(2), Abstract P89, 2005. |
| Knebel B, Bergsma T, Gibiansky L, Hane JT, Gastonguay MR. NMQual: A Tool to Automate Installation and Facilitate Qualification of NONMEM. PAGE Annual Meeting: Abstracts, 2005. |
| Gastonguay MR and Hane JT. The Importance of the Simulation Expectation as a Goodness of Fit Diagnostic for Categorical Population Pharmacodynamic Models. The AAPS Journal; 6(S1), Abstract W4355, 2004. |
| Gastonguay MR and Bies R. Estimation and Prediction of Chaotic Pharmacodynamic Systems Using Nonlinear Mixed-Effects Models: The Butterfly Effect. The AAPS Journal; 6(S1), Abstract W4353, 2004. |
| Gastonguay MR. A Full Model Estimation Approach for Covariate Effects: Inference Based on Clinical Importance and Estimation Precision. The AAPS Journal; 6(S1), Abstract W4354, 2004. |
| Gibiansky L. NONMEM Non-Influential Correlated ETAs Bug and How to Fix It. AAPS Annual Meeting: PPDM Poster-Podium Session, 2004. |
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